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International multidisciplinary cosensus report on definitions, diagnostic criteria, and management of fatty pancreas: A joint statement endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG.
United European Gastroenterol. J. 14:e70185 (2026)
This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing terminology and diagnostic frameworks, the report also synthesizes current knowledge across a wide range of relevant domains. These include the etiology and epidemiology of fatty pancreas, as well as its associations with alcohol consumption, smoking, acute and chronic pancreatitis, pancreatic exocrine insufficiency, type 2 diabetes mellitus, and surgical outcomes. The potential links between fatty pancreas and neoplastic conditions such as intraductal papillary mucinous neoplasms and pancreatic cancer are also addressed, alongside the current understanding of its metabolic implications (beta-cell function and glucose homeostasis) and treatment strategies. Throughout the consensus process, a consistent theme emerged: the limited availability of high-quality, prospective clinical data. Therefore, many of the recommendations in this report are based on expert consensus rather than strong empirical evidence. As such, the statements require rigorous prospective validation before they can be adopted into routine clinical practice. This underscores a critical need for further research, particularly studies aimed at clarifying causal relationships, validating diagnostic tools, and determining the clinical relevance of fatty pancreas across diverse patient populations. This report serves as both a summary of our current understanding and a roadmap for future investigations, aiming to close existing knowledge gaps and guide evidence-based clinical practice in this emerging field.
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Publication type
Article: Journal article
Document type
Guideline
Keywords
Acute Pancreatitis ; Beta‐cell ; Chronic Pancreatitis ; Diabetes Mellitus ; Fatty ; Intraductal Papillary Mucinous Neoplasms ; Metabolic Syndrome ; Pancreas ; Pancreatic Cancer ; Pancreatic Exocrine Insufficiency; Beta-cell Function; Post-hoc Analysis; Body-mass Index; Ectopic Fat; Metabolic Syndrome; Endoscopic Ultrasound; Liver-disease; Risk-factors; Cystic-fibrosis; Postoperative Complications
ISSN (print) / ISBN
2050-6406
e-ISSN
2050-6414
Quellenangaben
Volume: 14,
Issue: 1,
Article Number: e70185
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Grants
Swedish Society for Development of Pancreatology, Stockholm, Sweden
Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey