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Gene anschalten statt umbauen: CRISPR aktiviert Zellprogramme ohne DNA-Eingriff.
BioSpektrum 32, 31-34 (2026)
Activating genes in their endogenous genomic context is essential for
studying gene regulation and cell identity, but was long technically
limited. CRISPR-based gene activation (CRISPRa) enables programmable
transcriptional control at native loci. DNA-free CRISPRa
ribonucleo-proteins (dRNPs) allow transient, multiplexed gene activation
without genomic modification and enable controlled modulation of
cellular states, with potential relevance for future translational
applications.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Journal
BioSpektrum
Quellenangaben
Volume: 32,
Issue: 1,
Pages: 31-34
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)