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Open Access Green as soon as Postprint is submitted to ZB.
Fat bolsters tumours against ferroptosis.
Nat. Cell Biol. 28, 651–652 (2026)
Tumour location dictates ferroptosis resistance. A study indicates that peritumoural adipose tissue aids tumours in evading ferroptosis by supplying tryptophan metabolites, including kynurenine and 3-hydroxykynurenine, which block NCOA4-mediated ferritinophagy to lower levels of labile iron and suppress lipid peroxidation.
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Publication type
Article: Journal article
Document type
Comment, Opinion
Keywords
Cancer-cells
ISSN (print) / ISBN
1465-7392
e-ISSN
1476-4679
Journal
Nature Cell Biology
Quellenangaben
Volume: 28,
Pages: 651–652
Publisher
Nature Publishing Group
Publishing Place
Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status
Peer reviewed
Institute(s)
Institute of Metabolism and Cell Death (MCD)
Grants
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)