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Mühlberg, K. ; Schürfeld, R.* ; Kieser, P.* ; Uhlemann, S.* ; Stumvoll, M.* ; Scheinert, D.* ; Blüher, M. ; Fasshauer, M.* ; Ebert, T.*

An adipocytokine signature improves diagnostic accuracy for people living with lipoedema.

Br. J. Dermatol., DOI: 10.1093/bjd/ljag103 (2026)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Lipoedema is a chronic adipose tissue disorder often misdiagnosed as obesity due to overlapping symptoms and a lack of biomarkers. In this study, we analysed 13 adipocytokines in 79 women and identified chemerin, FGF21 and adiponectin as key biomarkers for distinguishing lipoedema. Decision tree models achieved up to 95% sensitivity, supporting the potential of these biomarkers for improving diagnostic accuracy, particularly in women with overweight or obesity.
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Publication type Article: Journal article
Document type Letter to the Editor
ISSN (print) / ISBN 0007-0963
e-ISSN 1365-2133
Journal British Journal of Dermatology - BJD
Publisher Wiley
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants AstraZeneca
University Leipzig
Karolinska Institutet Research Foundation
Karolinska Institutet
European Foundation for the Study of Diabetes
Novo Nordisk
German Research Foundation
German Diabetes Association