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Spies, R.* ; Ufer, G.* ; Sabia, R.* ; Hummel, J.* ; Peter, A. ; Wagner, R. ; Heni, M.*

Post-OGTT hypoglycaemia in newly diagnosed type 2 diabetes: Frequency, characteristics and cluster assignment.

Diabetologia (2026)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
AIMS/HYPOTHESIS: The aim of this study was to assess the frequency and metabolic characteristics of post-OGTT hypoglycaemia during an OGTT in individuals newly diagnosed with type 2 diabetes. METHODS: We analysed 97 extended (180 min) 75 g OGTTs from individuals newly diagnosed with type 2 diabetes. Glucose, insulin and C-peptide were measured at fasting and post-challenge time points. Insulin sensitivity was assessed using the oral glucose insulin sensitivity (OGIS) index and beta cell function was measured using the insulinogenic index (IGI) and Stumvoll's second-phase index. All participants were assigned to the Ahlqvist diabetes clusters. RESULTS: Post-OGTT hypoglycaemia (glucose ≤3.9 mmol/l at 180 min) occurred in 8.2% of the OGTTs analysed. Compared with individuals without hypoglycaemia, individuals with post-OGTT hypoglycaemia had a significantly lower BMI and higher insulin sensitivity, without differences in beta cell function. All individuals with hypoglycaemia were assigned to the mild obesity- or age-related diabetes Ahlqvist clusters. CONCLUSIONS/INTERPRETATION: Post-OGTT hypoglycaemia is present in a subset of individuals newly diagnosed with type 2 diabetes and is associated with higher insulin sensitivity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetes Subtypes ; Insulin Sensitivity ; Oral Glucose Tolerance Test ; Post-ogtt Hypoglycaemia ; Reactive Hypoglycaemia ; Type 2 Diabetes; Glucose
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Journal Diabetologia
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Universittsklinikum Ulm (8941)
ERC Consolidator Grant