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Kostiniuk, D.* ; Blankenstein, A.* ; Rajic, S.* ; Ciantar, J.* ; Mononen, N.* ; Lyytikainen, L.* ; Seppala, I.* ; Mishra, P.P.* ; Juonala, M.* ; Waldenberger, M. ; Elovainio, M.* ; Oksala, N.* ; Kahonen, M.* ; Hutri, N.* ; Raitakari, O.* ; Kleber, M.E.* ; Marz, W.* ; Lehtimaki, T.* ; Marttila, S.* ; Raitoharju, E.*

Prognostic potential of circulatory miR-19a-3p, miR-19b-3p, and miR-329-3p for future hypertension diagnosis.

J. Hypertens. 44, 811-822 (2026)
Publ. Version/Full Text Research data DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
MicroRNAs have been suggested as essential hypertension biomarkers, but evidence remains inconclusive due to limited high-throughput studies in population cohorts. We analyzed data from the Young Finns Study (YFS) from 2011 and 2018-2020 to assess cross-sectional and prospective associations between circulatory microRNAs, blood pressure (BP), and hypertension. Hypertension risk prediction potential was assessed using nested logistic and Weibull survival models; model performance was evaluated with likelihood ratio (LR) test and c-statistic. All models were adjusted with relevant risk factors. In 2011, whole blood microRNAs were profiled for 871 individuals (83 with hypertension); in 2018-2020, 760 were re-examined, with 67 newly diagnosed. Cross-sectionally, 16 miRNAs correlated with BP (Spearman, P-FDR < 0.05); miR-122-5p (fold change = 1.33) and miR-144-5p (fold change = -1.10) differentiated hypertensive individuals (U test, P-FDR < 0.05). Associations persisted in adjusted regression models and some replicated in LURIC (n = 999) and YFS serum data (n = 126). Prospectively, miR-19a-3p [odds ratio (OR) = 1.51, 95% confidence interval (95% CI): 1.14-2.18], miR-19b-3p (OR = 1.50, 95% CI:1.11-2.04), and miR-329-3p (OR = 0.58, 95% CI: 0.39-0.74) levels prognosed hypertension incident. miR-329-3p improved model fit (LR test, P = 2.85 & times;10(-4)) and discrimination (c-statistic = 0.849, Delta = 0.026). miR-19b-3p predicted time to onset (hazard ratio = 2.13, 95% CI: 1.38-4.45), improving model fit (LR test, P = 0.0012) and time-dependent discrimination at 7 and 8-year horizons. Our findings highlight both novel and previously reported miRNAs associating with BP and hypertension and suggest that miR-329-3p, miR-19a-3p, and miR-19b-3p as promising candidates for further investigation in hypertension risk prediction.
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Publication type Article: Journal article
Document type Scientific Article
Keywords blood pressure; essential hypertension; miRNA; prospective study; Blood Mononuclear-cells; Cardiovascular Risk; Expression Level; Differential Expression; Micrornas; Profile; Neovascularization; Metabolism; Inhibition; Biomarkers
ISSN (print) / ISBN 0263-6352
e-ISSN 1473-5598
Journal Journal of Hypertension
Quellenangaben Volume: 44, Issue: 5, Pages: 811-822 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants Cancer Foundation Finland
Finnish Foundation for Cardiovascular research
Tampere City Science Fund
Social Insurance Institution of Finland
Juho Vainio Foundation
Paavo Nurmi Foundation
Finnish Cultural Foundation
Sigrid Juselius Foundation
Tampere Tuberculosis Foundation
Emil Aaltonen Foundation
Yrjo Jahnsson Foundation
Signe and Ane Gyllenberg Foundation
Diabetes Research Foundation of Finnish Diabetes Association
Tampere University Hospital Supporting Foundation
Finnish Society of Clinical Chemistry
Aarne Koskelo Foundation