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The potential of wheat spatial omics.

Nat. Genet., DOI: 10.1038/s41588-026-02542-w (2026)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Wheat is a major staple crop for over one-third of the world's population, crucial for global food security, economic stability and cultural traditions. Recently, single-cell and spatial omics approaches have transformed biological discovery, primarily in medical and animal sciences, and they are now beginning to be applied in plant research. Here we summarize the technical innovations and feasibility of spatial omics applications in wheat research, particularly for understanding developmental and environmental responses, thereby potentially enhancing wheat breeding. We highlight how these tools can reveal spatial and temporal patterns in gene expression, cellular heterogeneity and tissue organization in wheat. Furthermore, we propose developing a spatially resolved single-cell atlas of wheat across its life cycle to facilitate breakthroughs in basic research and potential applications in breeding. To achieve these goals, we advocate for a Wheat Spatial Omics Consortium to foster worldwide collaboration for overcoming barriers and developing sustainable and climate-resilient wheat.
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Publication type Article: Journal article
Document type Review
Keywords Expression; Strategies; Efficiency; Traits; Future; Genes
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Research Unit Plant Genome and Systems Biology (PGSB)
Research Unit BioGeoChemistry and Analytics (BGC)
Grants Plant SpatioTemporal Omics Consortium
Australian Research Council
Grain Research and Development Corporation
WA Agricultural Research Collaboration (Wheat NUE)
Biological Breeding National Science and Technology Major Project
National Key R&D Program of China
Key Research and Development Program of Zhejiang