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Valasarajan, C.* ; Rasper, T.* ; Wilhelm, J.* ; Dhakad, D. ; Kuhnert, S.* ; Seeger, W.* ; Dimmeler, S.* ; Bals, R.* ; Savai, R.* ; Yildirim, A.Ö. ; Zeiher, A.* ; Pullamsetti, S.S.*

Loss of Y chromosome associates with lung and cardiac dysfunction in COPD.

Compr. Physiol. 16:e70142 (2026)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
This study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanistic basis for sex-biased vulnerability in COPD.
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Publication type Article: Journal article
Document type Editorial
ISSN (print) / ISBN 2040-4603
e-ISSN 2040-4603
Journal Comprehensive Physiology
Quellenangaben Volume: 16, Issue: 2, Pages: , Article Number: e70142 Supplement: ,
Publisher Wiley
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Grants Max-Planck-Gesellschaft
Deutsches Zentrum für Lungenforschung