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Fan, T.* ; Xie, Q.* ; Chen, J.* ; Zeng, M.* ; Chen, S. ; Yang, H.* ; Ruan, G.* ; Yang, Q.* ; Zhang, Y.* ; Li, Y.* ; Cao, P.* ; Bennell, K.L.* ; Fu, S.N.* ; Hunter, D.J.* ; Ding, C.* ; Zhu, Z.*

Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis.

Rheumatology 65:keag179 (2026)
Postprint DOI PMC
Open Access Green
OBJECTIVE: To explore the associations between accelerometer-measured physical activity patterns and cardiovascular diseases (CVD), CVD-cause mortality, and all-cause mortality in people with osteoarthritis (OA). METHODS: OA participants from the UK biobank with ≥36 h of accelerometer data, collected over one-week, were analyzed. Moderate to vigorous physical activity (MVPA) patterns were classified as: 'weekend warriors' (≥150 min/week, >50% on 1-2 days), active regular (>150 min/week), or inactive (<150 min/week). Mean min per week of light physical activity (LPA) were categorized into quartiles based on the distribution in the analytical sample. RESULTS: Among 10 210 study participants (mean age 58.1 ± 7.1 years; 64.5% female) followed for a median of 6.9 years, there were 1,538 incident cases of CVD, and 358 deaths, including 90 from CVD. Compared with inactive MVPA, both weekend warrior (adjusted hazard ratio, aHR (95% CIs); 0.73 (0.64-0.82)) and active regular MVPA (0.75 (0.65-0.87)) significantly lowered the risks of incident CVD. Notably, only the weekend warrior group showed significant reductions in CVD-cause mortality (0.55, 0.33-0.92), and all-cause mortality (0.75 (0.59-0.96)). Higher levels of LPA may link to lower CVD, CVD-cause mortality, and all-cause mortality risks in a dose-response manner. Subgroup analysis indicated that more prominent associations were found in individuals with a body mass index >30 or those aged over 60. CONCLUSION: Engaging in a weekend warrior pattern may confer unique survival benefits for OA patients, especially among older adults and those with obesity. LPA may have dose-dependent protective effects for CVD and mortality risk in OA patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cardiovascular Disease ; Osteoarthritis ; Physical Activity; Knee Osteoarthritis; Hip
ISSN (print) / ISBN 1462-0324
e-ISSN 1462-0332
Journal Rheumatology
Quellenangaben Volume: 65, Issue: 5, Pages: , Article Number: keag179 Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
Grants Clinical Research Startup Program of Southern Medical University
National Natural Science Foundation of China
Noncommunicable Chronic Diseases-National Science and Technology Major