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Open Access Green as soon as Postprint is submitted to ZB.
Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.
Development 136, 253-262 (2009)
Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
GABA; Interneuron; Midbrain; Neurotransmitter; Mouse; Neurogenesis; Ventral tegmental area (VTA); Serotonin; Dorsal raphe; Rhombomere 1; mouse superior colliculus; inner-ear development; periaqueductal gray; cell fate; serotonergic neurons; spinal-cord; expression; differentiation; hindbrain; behavior
Language
english
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 136,
Issue: 2,
Pages: 253-262
Publisher
Company of Biologists
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
Scopus ID
62349137096
PubMed ID
19088086
Erfassungsdatum
2009-07-09