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Fast & fuelious: The malate-aspartate shuttle in brown adipocyte lipid metabolism.
FEBS J., DOI: 10.1111/febs.70557 (2026)
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate-aspartate shuttle (MAS) supports norepinephrine-induced lipolysis in brown adipocytes. Disruption of MAS during adrenergic activation impairs lipolysis without reducing respiration. These findings indicate that cytosolic redox balance influences thermogenic metabolism. By linking NAD+ regeneration to lipid metabolism, the study highlights the MAS as an important node coordinating metabolism, redox balance, and thermogenesis.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Brown Adipose Tissue ; Lipid Mobilization ; Malate–aspartate Shuttle ; Metabolic Redox Balance ; Thermogenesis; Glycolysis; Glucose
ISSN (print) / ISBN
1742-464X
e-ISSN
1742-4658
Journal
FEBS Journal, The
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
Else Krner-Fresenius-Stiftung
Deutsche Forschungsgemeinschaft
Deutsche Forschungsgemeinschaft