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Cell death in cancer.
Cell 189, 2322-2356 (2026)
"Evasion of cell death" is a hallmark of cancer, enabling transformed cells to withstand oncogenic and therapeutic stress. Restoring cancer cell death is an appealing strategy but requires a deep understanding of cell death programs. Over the past two decades, the cell death field has expanded from apoptosis to include necroptosis, pyroptosis, ferroptosis, and other emerging programs, reshaping cancer biology and revealing therapeutic opportunities. While apoptosis remains the primary radiation- and chemotherapy-induced cell death program, non-apoptotic programs can drive inflammatory responses and orchestrate the interplay among tumor, stroma, and immune components, influencing immunotherapy outcomes. Ferroptosis, an iron-dependent, lipid peroxidation-driven cell death modality, lacks a canonical induction signal and arises from perturbations in lipid, iron, and redox metabolism. This review presents a unified framework for understanding the roles of major cell death programs in cancer development, progression, and treatment response, as well as addressing resistance to cancer cell death and immune suppression. "Our bodies are made of cells that live, and just as surely, of cells that must die." -S. Brenner.
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Publication type
Article: Journal article
Document type
Review
Keywords
Mixed Lineage Kinase; Domain-like Protein; Chronic Lymphocytic-leukemia; Bcl-2 Family Proteins; Cytochrome-c Release; Anti-apoptotic Mcl-1; Programmed Necrosis; Tumor-necrosis; Gasdermin-d; Inflammatory Caspases
ISSN (print) / ISBN
0092-8674
e-ISSN
1097-4172
Journal
Cell
Quellenangaben
Volume: 189,
Issue: 8,
Pages: 2322-2356
Publisher
Elsevier
Publishing Place
Cambridge, Mass.
Reviewing status
Peer reviewed
Institute(s)
Institute of Metabolism and Cell Death (MCD)
Grants
Interuniversity BOF projects
National Natural Science Foundation of China
Cancer Council Victoria Grant in Aid
National Health and Medical Research Council (NHMRC)
European Research Council (ERC) under the European Union
BMBF program FERROPATH
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
DFG CRC TRR 353
Priority Program SPP 2306
Foundation against Cancer
Walter Benjamin Fellowship by the DFG
UGent Special Research Fund Methusalem
Excellence of Science Research Consortium
Research Foundation-Flanders
FWF RU5659 TARGET-MPN
FWF
EU
Tencent New Cornerstone Investigator Program
Basic Science Center Project of the National Natural Science Foundation of China (NSFC)
Deutsche Forschungsgemeinschaft (DFG)
National Natural Science Foundation of China
Cancer Council Victoria Grant in Aid
National Health and Medical Research Council (NHMRC)
European Research Council (ERC) under the European Union
BMBF program FERROPATH
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
DFG CRC TRR 353
Priority Program SPP 2306
Foundation against Cancer
Walter Benjamin Fellowship by the DFG
UGent Special Research Fund Methusalem
Excellence of Science Research Consortium
Research Foundation-Flanders
FWF RU5659 TARGET-MPN
FWF
EU
Tencent New Cornerstone Investigator Program
Basic Science Center Project of the National Natural Science Foundation of China (NSFC)
Deutsche Forschungsgemeinschaft (DFG)