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Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
Schizophr. Res. 138, 69-73 (2012)
A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28x10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Association; Genetic Overlap; Manic Depression; Psychotic Disorder; Cortex; Hippocampus
ISSN (print) / ISBN
0920-9964
e-ISSN
1573-2509
Journal
Schizophrenia Research
Quellenangaben
Volume: 138,
Issue: 1,
Pages: 69-73
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed