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Bis(p-formyl-phenyl)diselenide functionalized BODIPY sensor for sensitive recognition of superoxide anion and its biological study.
Main Group Chem., DOI: 10.1177/10241221261441531 (2026)
An organo-diselenide functionalized BODIPY probe was synthesized and its structure was confirmed through NMR spectroscopic analysis, including (1H, 13C and 77Se) along with mass spectrometric analysis. The reactivity of probe with various Reactive Oxygen Species (ROS) and biologically relevant thiols was systematically investigated. The probe selectively detect superoxide via "turn-off" fluorescence response with a detection limit of 9.65 & micro;M. The probe exhibited quick fluorescence quenching response towards superoxide anion without interference from other ROS and biothiols. Further, in addition to sensing capability, the probe was examined for biological activities, and was displayed significant antibacterial and anti-inflammatory properties, highlighting its potential applicability in both chemical sensing and biomedical studies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Organoselenium; BODIPY; Superoxide; Antibacterial activity; Anti-inflammatory activity; Reversible Fluorescent-probe; Peroxidase-like Activity; Glutathione-peroxidase; Organoselenium Compounds; In-vitro; Selenium; Peroxynitrite; Derivatives; Diselenide; Toxicology
ISSN (print) / ISBN
1024-1221
e-ISSN
1745-1167
Journal
Main Group Chemistry
Publisher
Sage
Publishing Place
2455 Teller Rd, Thousand Oaks, Ca 91320 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
University Grant Commission