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Rittgen, J.* ; Pütz, M.* ; Zimmermann, R.

Identification of fentanyl derivatives at trace levels with nonaqueous capillary electrophoresis-electrospray-tandem mass spectrometry (MSⁿ, n = 2, 3): Analytical method and forensic applications.

Electrophoresis 33, 1595-1605 (2012)

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Open Access Green as soon as Postprint is submitted to ZB.

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The identification of fentanyl derivatives at trace levels employing capillary electrophoresis coupled to electrospray ionization tandem mass spectrometry (CE-ESI-MSn, n = 2, 3) is presented. The studied synthetic opioid fentanyl and its derivatives have an exceeding analgesic potency which can be up to 8000 times higher that of morphine. Apart from their therapeutical applications, there is an abuse of them in the drug scene as a heroin substitute. The identification of these opioids at trace levels is of further significant forensic interest with respect to recent seizures of clandestine fentanyl laboratories in Germany. In this work, a nonaqueous capillary electrophoresis (NACE)-ESI-MSn procedure was developed for the separation and identification of six fentanyl derivatives including fentanyl, cis- and trans-methylfentanyl, sufentanil, alfentanil, and carfentanil. Their fragmentation pattern in MSn experiments were investigated as well as the influence of the sheath-liquid mixture and the influence of the inside diameter of the fused silica capillary on the peak shape and the signal to noise ratio. Method validation included determination of the detection limits (about 12 nmol/L) and the repeatability of migration time (at most 0.07% relative standard deviation). The NACE-MS procedure was successfully applied for the analysis of real samples from seizures in illegal fentanyl laboratories.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Capillary Electrophoresis-electrospray Ionization Mass Spectrometry; Fentanyl Derivatives; Forensic Toxicology; Illicit Drugs; Trace Analysis; TOXICOLOGICAL DETECTION; HUMAN URINE; DRUGS; CARFENTANIL; METABOLISM; 3-METHYLFENTANYL; DISCRIMINATION; QUANTITATION; EXTRACTION; PEPTIDES

ISSN (print) / ISBN 0173-0835

e-ISSN 1522-2683

Journal Electrophoresis

Quellenangaben Volume: 33, Issue: 11, Pages: 1595-1605

Publisher Wiley

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Cooperation Group Comprehensive Molecular Analytics (CMA)