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Chen, S.* ; Lekka, C.* ; Lemvig, J.* ; Yi, X.* ; Cnop, M.* ; Marchetti, P.* ; Marselli, L.* ; Xia, J.* ; Madsen, J.G.S.* ; Rodriguez-Calvo, T. ; Richardson, S.J.* ; Johnson, J.D.* ; MacDonald, P.E.*

From pancreas and islet resources to diabetes insights.

Diabetologia, DOI: 10.1007/s00125-026-06731-4 (2026)
Publ. Version/Full Text DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.
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Publication type Article: Journal article
Document type Review
Keywords Biobanking; Data repositories; Diabetes; Islets of Langerhans; Knowledge bases; Multi-omics; Open science; Review; Standardisation; Tissue phenotyping; Insulin-secretion; Cell-function; Organ Donors; Beta-cells; Data Sets; Transplantation; Langerhans; Biobank; Onset; Cryopreservation
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Journal Diabetologia
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
Grants Diabetes Canada
Belgian Fonds National de la Recherche Scientifique
Walloon Region strategic axis Fonds de la Recherche Scientifique (FRFS)-Walloon Excellence in Life Sciences and Biotechnology (WELBIO)