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Open Access Green as soon as Postprint is submitted to ZB.
miRNAs in islet biology and diabetes: Progress, gaps, and opportunities.
Diabetes 75, 1052-1066 (2026)
This perspective marks the commemoration of the 2024 Nobel Prize in Medicine for miRNA discovery and reflects on more than two decades of research linking miRNAs to islet biology and diabetes. We very briefly summarize key roles of islet miRNAs in β-cell development, function, and immune interactions and identify major gaps in current knowledge. We discuss emerging concepts in miRNA regulation, cellular heterogeneity, and therapeutic targeting, alongside ongoing challenges in biomarker validation. Our view underscores that integrating mechanistic, single-cell, and translational approaches will be essential to advance miRNA-based therapies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Pluripotent Stem-cells; Insulin-producing Cells; Pancreatic Beta-cells; Differentiation; Expression; Mir-375; Mirna; Overexpression; Induction; Expansion
ISSN (print) / ISBN
0012-1797
e-ISSN
1939-327X
Journal
Diabetes
Quellenangaben
Volume: 75,
Issue: 7,
Pages: 1052-1066
Publisher
American Diabetes Association
Publishing Place
Alexandria, VA.
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research (IDF)
Grants
Medical Research Council10.13039/501100000265
Steve Morgan Foundation - Diabetes UK
Breakthrough T1D
Diabetes UK10.13039/501100000361
Steve Morgan Foundation - Diabetes UK
Breakthrough T1D
Diabetes UK10.13039/501100000361