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Sauter, W. ; Rosenberger, A.* ; Beckmann, L.* ; Kropp, S.* ; Mittelstraß, K. ; Timofeeva, M.* ; Wölke, G. ; Steinwachs, A. ; Scheiner, D. ; Meese, E.* ; Sybrecht, G.* ; Kronenberg, F.* ; Dienemann, H* ; LUCY Consortium (*) ; Chang-Claude, J.* ; Illig, T. ; Wichmann, H.-E. ; Bickeböller, H.* ; Risch, A.*

Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer.

Cancer Epidemiol. Biomarkers Prev. 17, 1127-1135 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Matrix metalloproteinases (MMP) play a key role in the breakdown of extracellular matrix and in inflammatory processes. MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associated with tumor invasion and metastasis. Nine haplotype tagging and additional two intronic single nucleotide polymorphisms (SNP) of MMP1 were genotyped in a case control sample, consisting of 635 lung cancer cases with onset of disease below 51 years of age and 1,300 age- and sex-matched cancer-free controls. Two regions of linkage disequilibrium (LD) of MMP1 could be observed: a region of low LD comprising the 5' region including the promoter and a region of high LD starting from exon 1 to the end of the gene and including the 3' flanking region. Several SNPs were identified to be individually significantly associated with risk of early-onset lung cancer. The most significant effect was seen for rs1938901 (P = 0.0089), rs193008 (P = 0.0108), and rs996999 (P = 0.0459). For rs996999, significance vanished after correction for multiple testing. For each of these SNPs, the major allele was associated with an increase in risk with an odds ratio between 1.2 and 1.3 (95% confidence interval, 1.0-1.5). The haplotype analysis supported these findings, especially for subgroups with high smoking intensity. In summary, we identified MMP1 to be associated with an increased risk for lung cancer, which was modified by smoking.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Matrix Metalloproteinase 1; MMP1; lung cancer
ISSN (print) / ISBN 1055-9965
e-ISSN 1538-7755
Journal Cancer Epidemiology, Biomarkers & Prevention
Quellenangaben Volume: 17, Issue: 5, Pages: 1127-1135 Article Number: , Supplement: ,
Publisher American Association for Cancer Research (AACR)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)