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Fedorova, M.* ; Bendt, A.K.* ; Bertrand-Michel, J.* ; Fiehn, O.* ; Godzień, J.* ; Goracci, L.* ; Gruber, F.* ; Guan, X.L.* ; Han, X.* ; Holčapek, M.* ; Kuligowski, J.* ; Meikle, P.J.* ; Nepachalovich, P.* ; O’Donnell, V.B.* ; Orešič, M.* ; Penkov, S.* ; Petrović, S.* ; Potapov, A.* ; Prabutzki, P.* ; Righetti, L.* ; Ruskovska, T.* ; Shevchenko, A.* ; Simons, K.* ; Spickett, C.M.* ; Vvedenskaya, O.* ; Watts, J.* ; Wenk, M.R.* ; Witting, M. ; Xia, Y.* ; Yang, B.* ; Domingues, M.R.*

A lipidomics roadmap: From basic research to societal challenges.

Nat. Commun. 17:4778 (2026)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and organismal scales. In biomedical research, lipidomics is emerging as a powerful platform for biomarker discovery, enabling early diagnosis, prognosis, and therapeutic monitoring of cancer, metabolic, and neurodegenerative diseases. The field is also reshaping drug discovery by uncovering lipid-mediated pathways, identifying novel therapeutic targets, and refining assessments of drug efficacy and safety. Beyond medicine, lipidomic analyses are redefining food and nutrition science by elucidating how dietary lipids influence metabolic health and disease risk. In parallel, environmental and ecological lipidomics are emerging as powerful frameworks for assessing ecosystem health, tracking the impact of pollutants and exploring the biological consequences of climate change. Such approaches are also informing the discovery of sustainable lipid resources and the development of novel biotechnological and agricultural innovations. With its rapidly expanding analytical repertoire and cross-disciplinary relevance, lipidomics is poised to make substantial contributions to both fundamental biology and applied science. This Perspective aims to synthesise the current state of the field, delineate major analytical and conceptual challenges, and outline future directions for translating lipidomic knowledge into tangible societal and environmental benefits.
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Publication type Article: Journal article
Document type Review
Keywords Lipidomics ; Drug Discovery ; Biomarker Discovery ; Systems Biology ; Interface (matter) ; Basic Research ; Field (mathematics) ; Human Health ; Perspective (graphical); Coronary-artery-disease; Mass-spectrometry; Cardiovascular Risk; Lipids; Quantification; Ceramides; Diversity; Evolution; Search; Diet
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 17, Issue: 1, Pages: , Article Number: 4778 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) CF Metabolomics & Proteomics (CF-MPC)
Grants B.Y. acknowledges the grants of the Research Council of Finland (Decision No. 356891) and Business Finland (Decision No. 1675/31/2023).
MetEx+ ANR-21-ESRE-0035
MetaboHUB (JVCE) ANR-24-INBS-0012).
J.G. acknowledges the Ministry of Education and Science within the project ''Excellence Initiative - Research University''.
F.G. gratefully acknowledges the financial support of the Federal Ministry of Economy, Energy and Tourism of Austria and the National Foundation for Research, Technology, and Development of Austria to the Christian Doppler Laboratory for Skin Multimodal I
L.G. acknowledges the support of the Presidenza del Consiglio dei Ministri-Dipartimento per la Coesione Territoriale e per il Sud (CURI project, n. E67G23000200001).
P.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (grant number 565977762).
J.W. acknowledges the National Institutes of Health (R35GM152060).
This publication is based on work from COST Action EpiLipidNET, CA19105, supported by COST (European Cooperation in Science and Technology). M.F. lab is supported by ''Sonderzuweisung zur Untersttzung profilbestimmender Struktureinheiten'' by the SMW
S. Petrovic. acknowledges the support of The Ministry of Science, Technological Development and Innovation of the Republic of Serbia, Contract No. 451-03-136/2025-03/200015.
X.H. acknowledges the partial support of National Institute on Aging grants R01AG061872, R01AG085545, P30AG013319, and P30AG044271.
.R.D. lab is supported by FCT - Fundao para a Cincia e a Tecnologia I.P., under the project/grant UID/50006 + LA/P/0094/2020 (doi.org/10.54499/LA/P/0094/2020 (Centro de Estudos do Ambiente e Mar (CESAM)) and UID/50006 - Laboratoacut
J.B.M acknowledges the support of MetaboHUB infrastructure funded by the Agence Nationale de la Recherche under the France 2030 program (MetaboHUB ANR-11-INBS-0010