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Grote, V.* ; Schlosser, L.* ; Campoy, C.* ; Crehuá‐Gaudiza, E.* ; Demmelmair, H.* ; Ege, M.J. ; Escribano, J.* ; Galera-Martínez, R.* ; García-Santos, J.A.* ; Gruszfeld, D.* ; Guerlich, K.* ; Guillén-Sebastián, C.* ; Handel, U.* ; Jamka, M.* ; Jarocka‐Cyrta, E.* ; Książyk, J.* ; Mazur, A.* ; Parada, E.* ; Robredo-García, I.* ; Rodrı́guez, G.* ; Romańczuk, B.* ; Pipaon, M.S.d.* ; Tejón-Fernández, M.* ; Walkowiak, J.* ; Weichselbaum, E.* ; Witte, A.* ; Koletzko, B.*

Whole goat milk versus cow milk formula and atopic dermatitis in infants: A randomized clinical trial.

Clin. Nutr. 63, 9:106707 (2026)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
BACKGROUND AND AIMS: Atopic dermatitis (AD) poses a substantial burden on affected children and their families. The evidence of the role of feeding choices in infancy for AD development is limited. METHODS: This study is a two-arm, parallel, randomized, double-blind, controlled trial to assess the effect of infant feeding with whole goat milk formula (WGF) versus cow milk formula (CF) on AD development during the first year of life. Healthy term infants up to 3 months of age were enrolled in 6 Spanish and 4 Polish study centres, without AD risk selection. The primary outcome measure was AD diagnosed by study personnel at three study visits using the United Kingdom Working Party diagnostic criteria (ADPrimary). Reported doctor-diagnosed AD (ADDoctor) was a secondary outcome. Cumulative incidence in the first year of life was calculated. Incidence rate ratios (IRR) were estimated by Poisson regression. RESULTS: Data from 2132 infants were analyzed. 192 infants were diagnosed with ADPrimary and 245 with ADDoctor. The cumulative incidence rate of ADPrimary for both groups was 11.6 per 100 person-years without difference between WGF and CF (IRR: 1.00; 95%CI: 0.75, 1.32; p = 0.991). In the per-protocol population, the incidence of ADDoctor was lower in WGF than CF (IRR: 0.66; 95%CI: 0.49, 0.9; p = 0.008). In infants with parental history of AD, the protective effect of WGF was stronger: ADDoctor IRR 0.36 (95%CI: 0.17, 0.76; p = 0.007). CONCLUSION: This trial demonstrates that WGF can reduce the incidence of AD in formula-fed infants in the first year of life, especially in presence of parental history of AD. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04599946. Submitted: 2020-10-05.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Atopic Dermatitis ; Randomized Controlled Trial ; Cow Milk ; Cow's Milk Allergy ; Clinical Trial; Oriented Eczema Measure; Diagnostic-criteria; Prevalence; Severity; Disease; Growth
ISSN (print) / ISBN 0261-5614
e-ISSN 0261-5614
Journal Clinical Nutrition
Quellenangaben Volume: 63, Issue: , Pages: 9, Article Number: 106707 Supplement: ,
Publisher Elsevier
Publishing Place Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh Eh1 3af, Midlothian, Scotland
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
Grants Dairy Goat Cooperative (NZ) Limited
New Zealand Ministry for Primary Industries as part of the Caprine Innovations NZ Sustainable Food & Fibre Futures Partnership Programme
Charitable Else Kroner Fresenius Foundation, LMU
LMU university hospitals