PuSH - Publication Server of Helmholtz Zentrum München: Applying the illness-death model to estimate the incidence and remission of severe anxiety and depressive symptoms in the German National Cohort (NAKO).

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Ito, C.* ; Baune, B.T.* ; Berger, K.* ; Kurth, T.* ; German National Cohort (NAKO) Investigators (Peters, A.)

Applying the illness-death model to estimate the incidence and remission of severe anxiety and depressive symptoms in the German National Cohort (NAKO).

Eur. Psych. 69:e23 (2026)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

BACKGROUND: Epidemiological evidence on the incidence and remission of anxiety and depressive disorders is limited. We estimated age- and sex-specific incidence and remission rates of moderate-to-severe anxiety and depressive symptoms using the illness-death model. METHODS: The German National Cohort (NAKO) is a cohort of over 200,000 participants aged 19-74 at baseline. Prevalence of probable cases, estimated with the Generalized Anxiety Disorder Scale and the Patient Health Questionnaire data 2014-2019 across five regions, was related to general mortality rates and disorder-specific mortality rate ratios in the illness-death model. The partial derivative of prevalence was modeled as a function of incidence and remission, with parameters estimated via least-squares optimization through 2,000 bootstrap resamples. RESULTS: The highest incidence rates (per 1,000 person-years) occurred at ages 19-21 for anxiety symptoms: 4.07 (95% CI: 0.00-7.57) in women and 2.55 (0.00-4.94) in men; and at ages 28-34 for depressive symptoms: 4.41 (0.00-9.81) in women and 3.30 (0.00-7.34) in men, all in Hamburg. Remission rates (per 100 person-years) were highest at older ages. For anxiety symptoms, rates peaked at 71.8 years in women (4.10 [0.00-11.94]) and 64.2 years in men (3.00 [0.00-9.23]) in Freiburg. For depressive symptoms, the highest observed was at 74.0 years, both among women (6.61 [0.00-15.50] in Münster) and men (3.58 [0.00-11.51] in Berlin). CONCLUSIONS: Incidence and remission rates of anxiety and depressive symptoms can be estimated from prevalence and mortality data, revealing regional, sex-, and age-related variation. Validation with longitudinal data is warranted.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Keywords Anxiety ; Depression ; Illness-death Model ; Incidence ; Prevalence ; Remission

ISSN (print) / ISBN 0924-9338

e-ISSN 1778-3585

Journal European Psychiatry

Quellenangaben Volume: 69, Issue: 1, Article Number: e23

Publisher Elsevier

Publishing Place Paris

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)