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Niu, Y.* ; Chen, R.* ; Sera, F.* ; Urban, A.* ; Vicedo-Cabrera, A.M.* ; Honda, Y.* ; Huber, V.* ; Guo, Y.* ; Tong, S.* ; Coêlho, M.d.S.Z.S.* ; Saldiva, P.H.N.* ; Lavigne, E.* ; Correa, P.M.* ; Ortega, N.V.* ; García, S.D.O.* ; Achilleos, S.* ; Royé, D.* ; Jaakkola, J.J.K.* ; Ryti, N.* ; Pascal, M.* ; Schneider, A.E. ; Breitner-Busch, S. ; Entezari, A.* ; Mayvaneh, F.* ; Raz, R.* ; Ng, C.F.S.* ; Hashizume, M.* ; Carrasco‐Escobar, G.* ; Silva, S.P.* ; Madureira, J.* ; Holobâcă, I.* ; Kim, H.* ; Lee, W.* ; Tobı́as, A.* ; Iñiguez, C.* ; Guo, Y.L.* ; Pan, S.* ; Li, S.* ; Masselot, P.* ; Bell, M.L.* ; Zanobetti, A.* ; Schwartz, J.* ; Gasparrini, A.* ; Kan, H.*

Association of mortality and combined oxidative capacity of ozone and nitrogen dioxide.

Nat. Sustain., DOI: 10.1038/s41893-026-01875-y (2026)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Ozone (O3) and nitrogen dioxide (NO2) are two common gaseous pollutants that both possess oxidizing properties with consequences for human health and have an inextricable chemical relationship that could have distinct public health impacts when considered in combination. We examined the short-term associations of the combined oxidative capacity of O3 and NO2 (represented by Oxwt, the average of O3 and NO2 concentrations weighted by their standard electrode potential) with total, cardiovascular and respiratory mortality in 380 cities across 23 countries or regions between 1985 and 2020. Over 2 days (LAG01), a 10-ppb increase in Oxwt concentration was associated with an increase of 0.82% (95% confidence interval (CI): 0.55%, 1.10%) in total mortality, 1.09% (95% CI: 0.83%, 1.35%) in cardiovascular mortality and 0.88% (95% CI: 0.31%, 1.45%) in respiratory mortality. We also observed variations in this association by geographic region and study period. More deaths were attributable to Oxwt than to either O3 or NO2 but fewer than the sum of the two. Thus, Oxwt might be a valuable indicator for use in public health efforts to capture the combined effects of O3 and NO2.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Nitrogen Dioxide ; Ozone ; Pollutant ; Oxidative Phosphorylation ; Air Pollutants ; Respiratory System ; Oxidizing Agent; Particulate Air-pollution; Combined Oxidant Capacity; Supplementation; Matter
ISSN (print) / ISBN 2398-9629
e-ISSN 2398-9629
Journal Nature Sustainability
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants National Key Research and Development Program of China
National Natural Science Foundation of China
Shanghai Municipal Science and Technology Major Project