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Berger, K.* ; Karch, A.* ; Lill, C.M.* ; Berger, T.L.* ; Mueller, U.* ; Bartl, M.* ; Mollenhauer, B.* ; Fischer, B.* ; Michels, K.B.* ; Meyer, P.T.* ; Katzke, V.A.* ; Sabin, J.* ; Sn, W.* ; Keil, T.* ; Castell, S.* ; Hauri, A.M.* ; Schulze, M.B.* ; Schikowski, T.* ; Riedel, O.* ; Pischon, T.* ; Velásquez, I.M.* ; Heinzel, S.* ; Brenner, H.* ; Peters, A. ; Mikolajczyk, R.* ; Herrmann, T.* ; Trenkwalder, C.*

A comprehensive assessment of lifecourse and mortality of Parkinson’s disease in the German National Cohort.

npj Parkinsons Dis. 12:156 (2026)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
A strong increase in the prevalence and deaths of Parkinson's disease (PD) has been reported over the last three decades. Ageing societies, genetic and environmental factors and access to health care contribute to these increases. Using data of the German National Cohort (NAKO) PD classifications based on self-report, claims data and a brief medication based algorithm to increase validity in the absence of neurologic examinations, were compared and the PD incidence, selected non-motor symptoms, functions and vital status were analysed. The algorithm based PD prevalence among 205.000 participants was 0.13% but it was 2.5-fold higher in claims data. Self-reported PD incidence was 0.13% over a median of 4.8 years follow-up, but cases had a 4-fold higher mortality, worse emotional, motoric and olfactory functions and higher prevalences of diabetes, obesity, depression and anxiety. The algorithm based PD prevalence and the mortality risk was similar to considerable older population studies from Europe.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cohort ; German ; Disease ; Incidence (geometry) ; Depression (economics) ; Cohort Effect ; Cohort Study ; Population; Diagnostic-criteria; Older; Resistance; Disorders; Features; Trial
ISSN (print) / ISBN 2373-8057
e-ISSN 2373-8057
Journal npj Parkinson's Disease
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 156 Supplement: ,
Publisher Springer
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants Projekt DEAL