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Free by publisher: Publ. Version/Full Text online available 07/2028
as soon as is submitted to ZB.
The mitochondrial calcium uniporter: From parts to signaling networks.
Cold Spring Harbor Perspect. Biol., DOI: 10.1101/cshperspect.a041770 (2026)
DOI
PMC
Mitochondria act as dynamic signaling hubs, constantly adapting to
tissue-specific metabolic demands to ensure cell homeostasis. Central to
this role is their capacity to take up calcium (Ca2+) into
the matrix, a process that regulates energy production, cell death
pathways, and broader cellular signaling. For decades, mitochondrial Ca2+ (mt-Ca2+)
uptake was firmly established at the physiological level, yet the
identity of the proteins involved remained elusive. The breakthrough
discovery of the mitochondrial calcium uniporter complex (MCUC) has
finally enabled genetic dissection of mt-Ca2+ fluxes and
revealed its pivotal role in health and disease. Here, we retrace the
trajectory of the field from the pioneering observations of the 1960s to
the molecular era of the MCUC, emphasizing the latest advances in its
regulation, integration into cellular networks, and pharmacological
targeting.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Calcium Signaling ; Signal Transduction ; Calcium ; Mitochondrion ; Cell Signaling
e-ISSN
1943-0264
Publisher
Cold Spring Harbor Laboratory Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)