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Chen, B.* ; Prabhu, A.* ; Guo, L.* ; Kaltenbach, A.* ; Wang, Y.* ; Shakir, G.* ; Natarelli, L.* ; Megens, R.T.A.* ; Jansen, Y.* ; Ramanathan, S.* ; Geiger, M.* ; Faußner, A.* ; Hristov, M.* ; Richter, D.* ; Di, X.* ; Stelt, M.v.d.* ; Triantafyllidou, V.* ; Li, Z.* ; Sachs, N.* ; Paloschi, V.* ; Mäegdefessel, L.* ; Hofmann, S.M. ; Schifferer, M.* ; Simons, M.* ; Weber, C.* ; Santovito, D.* ; Herzig, S. ; Guillamat‐Prats, R.* ; Steffens, S.

Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake.

Nat. Commun. 17:5939 (2026)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Peripheral cannabinoid CB1 receptor antagonists that lack central nervous system effects are emerging as promising therapies for metabolic disease, yet the role of endothelial CB1 signaling in atherosclerosis remains unclear. Here, we show that endothelial CB1 is expressed in human atherosclerotic plaques, is induced by oscillatory shear stress in atheroprone flow regions, and promotes vascular inflammation, permeability and lipid uptake. Endothelial-specific Cnr1 deletion or peripheral CB1 antagonism in mice attenuates atherosclerosis, reduces endothelial caveolae–dependent low-density lipoprotein uptake by downregulating caveolin-1 and ALK1 expression, and improves metabolic parameters in brown and white adipose tissue and the liver. The anti-atherogenic and metabolic effects are more pronounced in females, which is possibly linked to estrogen signaling. These findings identify endothelial CB1 as a proatherogenic, sex-biased regulator of vascular lipid transport and plaque development and associated metabolic dysfunction.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cannabinoid Receptor ; Endocannabinoid System ; Cannabinoid ; Adipose Tissue ; Inflammation ; Regulator ; Receptor ; Endothelium ; Lipid Metabolism
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 17, Issue: 1, Pages: , Article Number: 5939 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Regeneration Research (IDR)
Grants Deutsche Forschungsgemeinschaft (German Research Foundation)