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Damirov, F.* ; Ke, J.* ; Karimbayli, J.* ; Stoleriu, M.-G. ; Dreher, S.* ; Boedeker, E.* ; Gerz, S.* ; Hatz, R.* ; Preissler, G.*

Major postoperative complications and survival after lung cancer resection in patients aged ≥80 years: Risk factor analysis.

Curr. Oncol. 33:405 (2026)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
This study aimed to identify risk factors for major postoperative complications (TMM) and their impact on overall survival in patients aged ≥80 years undergoing lung cancer surgery, a group at increased risk of morbidity. A total of 88 patients aged ≥80 years who underwent anatomical lung resections were retrospectively analyzed. Postoperative complications were classified into minor or no complications (TMM 0–2) and major (TMM ≥ 3) complications. Logistic regression analysis was performed to identify independent predictors of major complications. Kaplan–Meier estimates were used to measure overall survival. Major complications occurred in 24 patients (27.3%). Multivariable regression analysis identified perioperative blood transfusion as an independent risk factor for major complications (p = 0.0009). Patients with major complications exhibited significantly reduced overall survival (p = 0.0009). Subgroup analysis revealed that patients who underwent minimally invasive surgery had significantly better survival (p = 0.01). Moreover, perioperative transfusion correlated with diminished overall survival (p = 0.0027). In patients aged ≥80 years undergoing lung resections, the occurrence of major postoperative complications is associated with significantly impaired survival. Minimally invasive surgical approaches and blood conservation strategies may mitigate complications and enhance long-term outcomes in this high-risk group.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Perioperative ; Lung Cancer ; Logistic Regression ; Risk Factor ; Blood Transfusion ; Proportional Hazards Model ; Subgroup Analysis ; Survival Analysis
ISSN (print) / ISBN 1198-0052
e-ISSN 1718-7729
Journal Current Oncology
Quellenangaben Volume: 33, Issue: 7, Pages: , Article Number: 405 Supplement: ,
Publisher MDPI
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)