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as soon as is submitted to ZB.
Optimizing inhalation therapy: A computational investigation of ellipsoidal particles in dry powder inhalers.
Comp. meth. biomech. biomed. engin. imag. visual., DOI: 10.1080/10255842.2026.2704680 (2026)
Targeted drug delivery seeks to maximize drug deposition in specific respiratory regions while minimizing undesired deposition. This study numerically investigated micron-sized particle deposition in a realistic human tracheobronchial model using an Eulerian–Lagrangian approach. Ellipsoidal particles with a fixed minor axis of 3.6 μm and aspect ratios of 1–10 were analyzed at inhalation flow rates of 30, 60, and 90 L/min. Compared with spherical particles, ellipsoidal particles reduced mouth–throat deposition and enhanced penetration into deeper lungs. At 60 L/min, particles with an aspect ratio of 3 increased deep-lung penetration by 6%, demonstrating their potential for targeted pulmonary drug delivery.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Computational Fluid Dynamics (cfd) ; Ellipsoidal Particle ; Human Respiratory System ; Particle Deposition ; Pulmonary Drug Delivery; Air-flow; Aerosol Deposition; Human Lung; Realistic Model; Simulation; Delivery; Fraction; Laminar; Fibers; Fluid
ISSN (print) / ISBN
2168-1163
e-ISSN
2168-1171
Publisher
Taylor & Francis
Publishing Place
Abingdon
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
Grants
Center for International Scientific Studies and Collaboration (CISSC) of the Ministry of Science, Research and Technology of Iran