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Tigu, A.B.* ; Ivancuta, A.* ; Tomuleasa, C.* ; Nistor, M.* ; Kegyes, D.* ; Cenariu, D.* ; Munteanu, R.* ; Buzoianu, A.D.* ; Einsele, H.* ; Federico, M.* ; Kobold, S. ; Gulei, D.* ; Ciechanover, A.*

Proteolysis targeting chimeric-based technology in myeloma and lymphoma.

Mol. Cancer Ther. 25, 1264-1280 (2026)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Proteolysis-targeting chimeras (PROTAC) leverage the ubiquitin-proteasome system to selectively degrade oncogenic proteins, including those previously seen as undruggable. Recent preclinical studies indicate that PROTACs may represent a novel therapeutic strategy in lymphoma and myeloma. Indeed, preclinically, PROTACs have shown high efficacy and remarkable selectivity, a favorable safety profile, and lower toxicity compared with conventional therapies. Their catalytic, reusable mechanism enables drug dosing and offers the perspective of long-term low-dose treatment. PROTACs have demonstrated their ability to overcome drug resistance by targeting and degrading overexpressed or mutant proteins that are responsible for refractory disease. This review aims to offer a comprehensive evaluation of the currently existing PROTACs that have been tested in lymphoma and myeloma to highlight the need for drug optimization and further translational research that could translate PROTACs to clinical trials.
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Publication type Article: Journal article
Document type Review
Keywords B-cell Lymphoma; Itk Inhibitors; Protac Design; Degradation; Pathway; Cancer; Resistance; Family; Potent; Bcl6
ISSN (print) / ISBN 1535-7163
e-ISSN 1538-8514
Journal Molecular Cancer Therapeutics
Quellenangaben Volume: 25, Issue: 8, Pages: 1264-1280 Article Number: , Supplement: ,
Publisher American Association for Cancer Research (AACR)
Publishing Place 615 Chestnut St, 17th Floor, Philadelphia, Pa 19106-4404 Usa
Reviewing status Peer reviewed
Institute(s) Unit for Clinical Pharmacology (KKG-EKLiP)
Grants International doctoral program "i-Target: immunotargeting of cancer" - Elite Network of Bavaria
Bavarian Cancer Research Center (TANGO)
Deutsche Forschungsgemeinschaft
Melanoma Research Alliance
Marie Sklodowska-Curie Training Network for Optimizing Adoptive T-Cell Therapy of Cancer - Horizon 2020 programme of the European Union
Marie Sklodowska-Curie Training Network for tracking and controlling therapeutic immune cells in cancer - Horizon Programme of the EU
Else Kroener-Fresenius-Stiftung (IOLIN)
Israel Cancer Research Fund USA
Adelson Medical Research Foundation
Romanian Research Ministry-PNRR
European Commission - Horizon Europe Framework Network
HORIZON-TMA-MSCA-DN
Romania
Moldova
Israel Science Foundation (ISF)
ISF
German Cancer Aid (AvantCAR.de)
Wilhelm-Sander-Stiftung
Ernst Jung Stiftung
Fritz-Bender Foundation
Deutsche Jose Carreras Leukaemie Stiftung
Hector Foundation
Bavarian Research Foundation (BAYCELLator)
Monika Kutzner Foundation
Bruno and Helene Joester Foundation (360degrees CAR)
Dr. Rurainski Foundation
Brigitte
SFB-TRR
European Research Council
Institutional Strategy LMUexcellent of LMU Munich
Go-Bio Initiative
The m4-Award of the Bavarian Ministry for Economic Affairs, Bundesministerium fuor Bildung und Forschung
EUROSTAR-Programm
Dr. Konstanze Wegener Foundation