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Open Access Green as soon as Postprint is submitted to ZB.
A lipid kinase joins the transcriptional machinery.
Nat. Cell Biol., DOI: 10.1038/s41556-026-02046-z (2026)
Long recognized for its roles in autophagy and endosomal trafficking, phosphatidylinositol 3-kinase class III (PI3K-3) is now shown to also function in the nucleus. A recent study shows that PI3K-3 associates with the transcriptional machinery and a chromatin-modifying complex, and contributes to transcriptional adaptation during fasting.
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Publication type
Article: Journal article
Document type
Comment, Opinion
Keywords
Phosphatidylinositol ; Autophagy ; Function (biology) ; Kinase ; Endosome ; Transcriptional Regulation
ISSN (print) / ISBN
1465-7392
e-ISSN
1476-4679
Journal
Nature Cell Biology
Publisher
Nature Publishing Group
Publishing Place
Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status
Peer reviewed
Institute(s)
Institiute of Functional Epigenetics (IFE)
Grants
Deutsche Forschungsgemeinschaft (German Research Foundation)