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Diósdi, A.* ; Theis, F.J. ; Horvath, P.

Towards 3D-oid models that integrate molecular, morphological and spatial cellular features.

Nat. Rev. Mol. Cell Biol., DOI: 10.1038/s41580-026-01025-4 (2026)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Methods to study cellular omics, morphology and spatial context evolved independently, yet evidence shows their integration outperforms single-methodology analyses. In this Comment, we propose that use of next-generation 3D-oids that combine molecular, morphological and spatial information will promote tissue analyses and bring us closer to engineering functional organs.
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Publication type Article: Journal article
Document type Comment, Opinion
Keywords Context (archaeology) ; Spatial Contextual Awareness ; Spatial Analysis ; Morphology (biology) ; Spatial Ecology
ISSN (print) / ISBN 1471-0072
e-ISSN 1471-0080
Journal Nature Reviews - Molecular Cell Biology
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of AI for Health (AIH)
Institute of Computational Biology (ICB)