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Ahmad, R.* ; Actis, O.* ; Aitkenhead, A.H.* ; Amos, R.A.* ; Bassler, N.* ; Burne, C.* ; Chaudhary, P.* ; Datzmann, G.* ; Deut, U.* ; Di Martino, F.* ; Habgood, R.* ; Jolly, S.* ; Jouglar, E.* ; Kasanda, E.* ; Lee, N.* ; Leiser, D.* ; Li, X.* ; Milluzzo, G.* ; Neubauer, J.* ; Ng Wei Siang, K.* ; Palmans, H.* ; Prezado, Y.* ; Reindl, J.* ; Romano, F.* ; Roncali, L.* ; Rousseti, A.* ; Schmid, T.E. ; Patallo, I.S.* ; Stephan, F.* ; Subiel, A.* ; Taylor, E.* ; Walpen, A.* ; Flynn, S.*

Roadmap for the implementation of particle minibeam therapy.

Med. Phys. 53:e70660 (2026)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Particle minibeam therapy (PMBT) has emerged as an advanced modality within spatially fractionated radiation therapy, using the physical properties of protons, ions, and electrons to achieve superior normal tissue sparing whilst preserving spatial dose distribution at depths that are unachievable in conventional kV or MV X-rays. As with any novel radiotherapy technique, successful translation into routine clinical practice requires robust evidence of efficacy, safety, and technical feasibility. This review presents a coordinated roadmap for the development and future implementation of PMBT, identifying the key challenges that must be addressed to enable safe and effective clinical implementation. This review highlights the interconnected nature of PMBT research and proposes the priority areas for future investigation, and the steps necessary to guide PMBT from experimental concept, towards clinical implementation. As most of the steps are relevant to all particle types, PMBT will be referred to in general, where specific particle types will be discussed where appropriate.
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Publication type Article: Journal article
Document type Review
Keywords Minibeam Therapy ; Particle Minibeam Therapy ; Pmbt Workshop; Microbeam Radiation-therapy; Ray Microplanar Beams; Bearing Rats; Proton; Radiotherapy; Dosimetry; Collimator; Models; Reduction; Criteria
ISSN (print) / ISBN 0094-2405
e-ISSN 1522-8541
Journal Medical Physics
Quellenangaben Volume: 53, Issue: 9, Pages: , Article Number: e70660 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
Grants National Measurements System Programmes Unit
National Institute for Nuclear Physics
UK Research and Innovation
Manchester Biomedical Research Centre
PRIN 2022 D.D. 104 February 2022