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Sleep disturbances and depressed mood: A harmful combination associated with increased leptin levels in women with normal weight.
Biol. Psychol. 89, 163-169 (2012)
Leptin, involved in energy regulation and contributor to cardiovascular disease, has been implicated to play a role in depression and sleep disturbances, two closely intertwined conditions. Previous results investigating leptin level alterations either in sleep disorders or in depression have been inconsistent. We investigate the association between leptin levels and the different combinations of depressed mood and sleep disturbances in 1369 subjects (706 men, 663 women), derived from the population-based MONIKA/KORA study. As leptin regulation is known to differ by sex and weight, analyses were performed in normal weight and overweight men and women separately. We found a highly significant association between leptin levels and the combination of depressed mood and sleep disturbances in normal-weight women (BMI ≤ 25) (p<0.01). No associations were found in men and in overweight women. Our results suggest that leptin regulation in depressed mood and sleep disturbances very much depend on sex and weight.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Leptin; Depressed mood; Sleep disturbances; Gender and weight effects; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MONICA/KORA AUGSBURG; PLASMA LEPTIN; MAJOR DEPRESSION; SERUM LEPTIN; MYOCARDIAL-INFARCTION; GENERAL-POPULATION; CHRONIC INSOMNIA
ISSN (print) / ISBN
0301-0511
e-ISSN
1873-6246
Journal
Biological Psychology
Quellenangaben
Volume: 89,
Issue: 1,
Pages: 163-169
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)