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Han, S.H.* ; Zhou, A.X.* ; Jamieson, A.M.* ; Wilson, A.A.* ; Zhou, B.* ; Weiss, D.J.* ; Jiang, D.* ; McKeon, F.* ; Chapman, H.* ; Miranda, H.* ; Schiller, H.B. ; Rajagopal, J.* ; Yun, J.H.* ; Que, J.* ; Engelhardt, J.F.* ; Basil, M.C.* ; Raredon, M.S.B.* ; Gu, M.* ; Ghosh, M.* ; Kadur Lakshminarasimha Murthy, P.* ; Tata, P.R.* ; Wang, R.* ; Davidson, S.* ; Majka, S.M.* ; Tesfaigzi, Y.* ; Gomez, C.R.* ; Lu, Q.* ; Ordovas-Montanes, J.* ; Kalhan, R.*

Progenitor resilience and the early onset of chronic lung diseases: NHLBI workshop report.

Am. J. Respir. Cell Mol. Biol. 74, 1332-1341 (2026)
Publ. Version/Full Text Research data DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Lung function peaks in young adulthood and declines with age. Studies suggest that this trajectory may be modifiable, potentially enhancing lung health and resilience to prevent or delay the onset of chronic lung disease. Although significant progress has been made in identifying the lung stem/progenitor cell populations involved in lung repair and homeostasis, their regulation and potential for manipulation to promote respiratory health and resilience remain elusive. To explore these issues, the NHLBI organized a virtual workshop on November 7-8, 2024, that aimed to cover the current scientific landscape; address critical research gaps; and identify challenges, opportunities, and key research questions related to chronic lung disease, with a focus on lung stem/progenitor resilience and its applications in the early diagnosis, prevention, and treatment of chronic lung diseases. This report summarizes the scientific presentations, discussions, and recommendations from the workshop.
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Publication type Article: Journal article
Document type Review
Keywords Chronic Lung Disease ; Lung Stem Cell ; Resilience; Obstructive Pulmonary-disease; Cystic-fibrosis; Stem-cells; Health; Model; Risk; Differentiation; Decline; Airways; Copd
ISSN (print) / ISBN 1044-1549
e-ISSN 1535-4989
Journal American Journal of Respiratory Cell and Molecular Biology
Quellenangaben Volume: 74, Issue: 10, Pages: 1332-1341 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Research Unit Precision Regenerative Medicine (PRM)
Grants NIA NIH HHS
NHLBI NIH HHS