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Liu, Y.* ; Tsuchida, H.* ; Kubota, S.* ; Kubota‐Okamoto, S.* ; Kato, T.* ; Horikawa, Y.* ; Tsunekawa, S.* ; Kuwata, H.* ; Fujiwara, Y.* ; Yamazaki, Y.* ; Yamada, Y.* ; Fujita, H.* ; Iizuka, K.* ; Murao, N. ; Ueno, S.* ; Seino, Y.* ; Suzuki, A.* ; Hayashi, Y.* ; Nakanishi, T.* ; Drucker, D.J.* ; Shiina, T.* ; Shimizu, Y.* ; Iwasaki, Y.* ; Yada, T.* ; Seno, Y.* ; Takahashi, Y.* ; Imaizumi, T.* ; Murakami, T.* ; Horowitz, M.* ; Seino, Y.* ; Yabe, D.*

Olive oil before oral glucose delays gastric emptying and lowers glycemia through partially redundant glucagon and GLP-1 signaling in mice.

Diabetes, DOI: 10.2337/db26-0531 (2026)

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We undertook this study to define how fat consumed before oral glucose attenuates postchallenge glycemia. We asked whether olive oil reduces glycemia by slowing gastric emptying and investigated contributing endocrine and neural pathways. Olive oil increased glucagon, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1; slowed gastric emptying; and reduced early glycemia in mice. Glucagon and glucagon-like peptide-1 signaling acted redundantly, with vagal involvement. Nutrient timing integrates endocrine-neural regulation of gastric emptying and glycemia, supporting evaluation of meal sequencing in humans.

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Publication type Article: Journal article

Document type Scientific Article

ISSN (print) / ISBN 0012-1797

e-ISSN 1939-327X

Journal Diabetes

Publisher American Diabetes Association

Publishing Place Alexandria, VA.

Reviewing status Peer reviewed

Institute(s) Institute for Diabetes und Organoid Technology (IDOT)
Institute of Metabolism and Cell Death (MCD)

Grants Japan Society for the Promotion of Science
Suzuken Memorial Foundation
Japan Agency for Medical Research and Development (AMED)
Japan Association for Diabetes Education and Care (JADEC)