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Open Access Green as soon as Postprint is submitted to ZB.
The impact of TGF-β on lung fibrosis: From targeting to biomarkers.
Ann. Am. Thorac. Soc. 9, 111-116 (2012)
Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis in different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant wound healing response during the initiation of fibrotic processes. Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating disease, in which TGF-βx{2013}induced disturbances of the homeostatic microenvironment are critical to promote cell activation, migration, invasion, or hyperplastic changes. In addition, excess extracellular matrix production contributes in a major way to disease pathogenesis. For this reason, this review will focus on discussing novel data and highlight growing interest in deepening the understanding of the profibrotic role of TGF-β and its direct or indirect targeting for disease modulation.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
2329-6933
e-ISSN
2325-6621
Quellenangaben
Volume: 9,
Issue: 3,
Pages: 111-116
Publisher
American Thoracic Society
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)