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The impact of TGF-β on lung fibrosis: From targeting to biomarkers.

Ann. Am. Thorac. Soc. 9, 111-116 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis in different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant wound healing response during the initiation of fibrotic processes. Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating disease, in which TGF-βx{2013}induced disturbances of the homeostatic microenvironment are critical to promote cell activation, migration, invasion, or hyperplastic changes. In addition, excess extracellular matrix production contributes in a major way to disease pathogenesis. For this reason, this review will focus on discussing novel data and highlight growing interest in deepening the understanding of the profibrotic role of TGF-β and its direct or indirect targeting for disease modulation.
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Publication type Article: Journal article
Document type Review
Corresponding Author
ISSN (print) / ISBN 2329-6933
e-ISSN 2325-6621
Quellenangaben Volume: 9, Issue: 3, Pages: 111-116 Article Number: , Supplement: ,
Publisher American Thoracic Society
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed