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Open Access Green as soon as Postprint is submitted to ZB.
The origin of diversity: Studying the evolution of multi-faceted CD8+ T cell responses.
Cell. Mol. Life Sci. 69, 1585-1595 (2012)
During the past two decades of research in T cell biology, an increasing number of distinct T cell subsets arising during the transition from naïve to antigen-experienced T cells have been identified. Recently, it has been appreciated that, in different experimental settings, distinct T cell subsets can be generated in parallel within the same immune response. While signals driving a single "lineage" path of T cell differentiation are becoming increasingly clear, it remains largely enigmatic how the phenotypic and functional diversification creating a multi-faceted T cell response is achieved. Here, we review current literature indicating that diversification is a stable trait of CD8(+) T cell responses. We showcase novel technologies providing deeper insights into the process of diversification among the descendants of individual T cells, and introduce two models that emphasize either intrinsic noise or extrinsic signals as driving forces behind the diversification of single cell-derived T cell progeny populations in vivo.
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Publication type
Article: Journal article
Document type
Review
Keywords
T cell memory; Subset diversity; Fate; Plasticity; Single T cell-derived progeny; Intrinsic noise; Extrinsic environmental cues; LINEAGE RELATIONSHIPS; SELECTIVE EXPRESSION; PROTECTIVE IMMUNITY; PRECURSOR FREQUENCY; PRIMITIVE ENDODERM; DENDRITIC CELLS; CENTRAL-MEMORY; CUTTING EDGE; LYMPH-NODES; EFFECTOR
ISSN (print) / ISBN
1420-682X
e-ISSN
1420-9071
Quellenangaben
Volume: 69,
Issue: 10,
Pages: 1585-1595
Publisher
Birkhäuser
Non-patent literature
Publications
Reviewing status
Peer reviewed