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Buchholz, V.R.* ; Gräf, P.* ; Busch, D.H.

The origin of diversity: Studying the evolution of multi-faceted CD8+ T cell responses.

Cell. Mol. Life Sci. 69, 1585-1595 (2012)
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During the past two decades of research in T cell biology, an increasing number of distinct T cell subsets arising during the transition from naïve to antigen-experienced T cells have been identified. Recently, it has been appreciated that, in different experimental settings, distinct T cell subsets can be generated in parallel within the same immune response. While signals driving a single "lineage" path of T cell differentiation are becoming increasingly clear, it remains largely enigmatic how the phenotypic and functional diversification creating a multi-faceted T cell response is achieved. Here, we review current literature indicating that diversification is a stable trait of CD8(+) T cell responses. We showcase novel technologies providing deeper insights into the process of diversification among the descendants of individual T cells, and introduce two models that emphasize either intrinsic noise or extrinsic signals as driving forces behind the diversification of single cell-derived T cell progeny populations in vivo.
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Publication type Article: Journal article
Document type Review
Keywords T cell memory; Subset diversity; Fate; Plasticity; Single T cell-derived progeny; Intrinsic noise; Extrinsic environmental cues; LINEAGE RELATIONSHIPS; SELECTIVE EXPRESSION; PROTECTIVE IMMUNITY; PRECURSOR FREQUENCY; PRIMITIVE ENDODERM; DENDRITIC CELLS; CENTRAL-MEMORY; CUTTING EDGE; LYMPH-NODES; EFFECTOR
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 1420-682X
e-ISSN 1420-9071
Journal Cellular and Molecular Life Sciences - CMLS
Quellenangaben Volume: 69, Issue: 10, Pages: 1585-1595 Article Number: , Supplement: ,
Publisher Birkhäuser
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-520100-001
G-501790-003
PubMed ID 22476589
DOI 10.1007/s00018-012-0967-8
WOS ID 000303509800004
Erfassungsdatum 2012-07-23
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