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Smit, L.A.* ; Kogevinas, M.* ; Antò, J.M.* ; Bouzigon, E.* ; Gonzalez, J.R.* ; Le Moual, N.* ; Kromhout, H.* ; Carsin, A.E.* ; Pin, I.* ; Jarvis, D.* ; Vermeulen, R.* ; Janson, C.* ; Heinrich, J. ; Gut, I.* ; Lathrop, M* ; Valverde, M.A.* ; Demenais, F.* ; Kauffmann, F.*

Transient receptor potential genes, smoking, occupational exposures and cough in adults.

Respir. Res. 13:26 (2012)
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Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. METHODS: Nocturnal, usual, and chronic cough, smoking, and job history were obtained by questionnaire in 844 asthmatic and 2046 non-asthmatic adults from the Epidemiological study on the Genetics and Environment of Asthma (EGEA) and the European Community Respiratory Health Survey (ECRHS). Occupational exposures to vapors, gases, dusts, and/or fumes were assessed by a job-exposure matrix. Fifty-eight tagging SNPs in TRPV1, TRPV4, and TRPA1 were tested under an additive model. RESULTS: Statistically significant associations of 6 TRPV1 SNPs with cough symptoms were found in non-asthmatics after correction for multiple comparisons. Results were consistent across the eight countries examined. Haplotype-based association analysis confirmed the single SNP analyses for nocturnal cough (7-SNP haplotype: p-global = 4.8 × 10-6) and usual cough (9-SNP haplotype: p-global = 4.5 × 10-6). Cough symptoms were associated with exposure to irritants such as cigarette smoke and occupational exposures (p < 0.05). Four polymorphisms in TRPV1 further increased the risk of cough symptoms from irritant exposures in asthmatics and non-asthmatics (interaction p < 0.05). CONCLUSIONS: TRPV1 SNPs were associated with cough among subjects without asthma from two independent studies in eight European countries. TRPV1 SNPs may enhance susceptibility to cough in current smokers and in subjects with a history of workplace exposures.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Asthma; Gene-environment interaction; Irritant exposure; Smoking; TRP channel; OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY HEALTH SURVEY; NEUROGENIC INFLAMMATION; TRPV4 CHANNEL; ASTHMA; ASSOCIATION; CELLS; POLYMORPHISMS; ENVIRONMENT; EXPRESSION
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 1465-9921
e-ISSN 1465-993X
Journal Respiratory Research
Quellenangaben Volume: 13, Issue: , Pages: , Article Number: 26 Supplement: ,
Publisher BioMed Central
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
PubMed ID 22443337
DOI 10.1186/1465-9921-13-26
WOS ID 000304058900001
Erfassungsdatum 2012-07-23
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