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Animal studies in restless legs syndrome.
Mov. Disord. 22, (Suppl.18), 459-465 (2007)
Although restless legs syndrome (RLS) is a common disorder that has been studied thoroughly in the past decades, the underlying pathophysiology is still not fully understood. However, some attractive hypotheses on the pathogenesis of the disorder have been forwarded. Animal models are an important tool to verify hypotheses and to dissect out the details of pathophysiological mechanisms. Ideally they might serve the development of future treatment strategies. This review discusses the general and specific prerequisites necessary for the establishment of animal models for RLS and summarizes the approaches that have been made.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
restless legs syndrome; RLS; periodic limb movements; PLM; animal; model
ISSN (print) / ISBN
0885-3185
e-ISSN
1531-8257
Journal
Movement Disorders
Quellenangaben
Volume: 22,
Issue: SUPPL. 18,
Pages: 459-465,
Supplement: (Suppl.18)
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)