PuSH - Publication Server of Helmholtz Zentrum München: Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

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Hösel, M.* ; Broxtermann, M. ; Janicki, H.* ; Esser, K. ; Arzberger, S. ; Hartmann, P.* ; Gillen, S.* ; Kleeff, J.* ; Stabenow, D.* ; Odenthal, M.* ; Knolle, P.* ; Hallek, M.* ; Protzer, U. ; Buning, H.*

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Hepatology 55, 287-297 (2012)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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Adeno-associated viral vectors (rAAV) are frequently used in gene therapy trials. Although rAAV vectors are of low immunogenicity, humoral as well as T cell responses may be induced. While the former limits vector reapplication, the expansion of cytotoxic

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Publication type Article: Journal article

Document type Scientific Article

Keywords B-VIRUS INFECTION; GENE-EXPRESSION; ACTIVATION; LIPOPOLYSACCHARIDE; HEPATOCYTES; INTERFERON; ADENOVIRUS

ISSN (print) / ISBN 0270-9139

e-ISSN 1527-3350

Journal Hepatology

Quellenangaben Volume: 55, Issue: 1, Pages: 287-297

Publisher Wiley

Publishing Place Hoboken, NJ

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)