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Open Access Green as soon as Postprint is submitted to ZB.
Typ-2-Diabetes-assoziierte Gene.
Diabetologie 8, 26-34 (2012)
Type 2 diabetes is becoming more and more important because the prevalence of the disease, which is characterized by reduced insulin sensitivity and secretion, keeps rising in the population. This dysfunction leads to a decreased glucose uptake in target tissues, whereby the blood glucose level eventually increases. In this process genetic as well as environmental factors play a role but the fundamental pathogenesis is still not fully understood. Numerous genes contributing to the manifestation have already been identified mainly via genome-wide association studies (GWAS). The main part of the heritability of type 2 diabetes as well as functional mechanisms remain unclear. The elucidation is the first step towards the development of improved as well as personalized therapeutic approaches.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Type 2 Diabetes ; Dna Variant ; Genome-wide Association Study (gwas) ; Therapy ; Gene; GENOME-WIDE ASSOCIATION; RISK; GLUCOSE; VARIANT; LOCI; SUSCEPTIBILITY; PREVENTION; OBESITY; TCF7L2; KCNQ1
ISSN (print) / ISBN
2731-7447
e-ISSN
2731-7455
Journal
Diabetologie, Die
Quellenangaben
Volume: 8,
Issue: 1,
Pages: 26-34
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Molecular Epidemiology (AME)