PuSH - Publication Server of Helmholtz Zentrum München

Yang, J.* ; Ferreira, T.* ; Morris, A.P.* ; Medland, S.E.* ; GIANT Consortium (Heid, I.M. ; Illig, T. ; Heinrich, J. ; Grallert, H. ; Gieger, C. ; Thiering, E.) ; DIAGRAM Consortium (Meitinger, T. ; Müller, M. ; Illig, T. ; Gieger, C. ; Albrecht, E. ; Wichmann, H.-E.) ; Madden, P.A.* ; Heath, A.C.* ; Martin, N.G.* ; Montgomery, G.W.* ; Weedon, M.N.* ; Loos, R.J.* ; Frayling, T.M.* ; McCarthy, M.I.* ; Hirschhorn, J.N.* ; Goddard, M.E.* ; Visscher, P.M.*

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.

Nat. Genet. 44, 369-375 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; COMMON SNPS; SUSCEPTIBILITY LOCI; GENETIC-VARIATION; HUMAN HEIGHT; HERITABILITY; DISEASE; RISK; MAP
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 44, Issue: 4, Pages: 369-375 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)