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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nat. Genet. 42, 937-948 (2010)
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Genome-wide association; Gastric-inhibitory polypeptide; Melanocortin-4 receptor gene; Glucose-homeostasis; Common variants; Adult obesity; Early-onset; Fat mass; Risk; Metanalysis
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Journal
Nature Genetics
Quellenangaben
Volume: 42,
Issue: 11,
Pages: 937-948
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed