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Open Access Green as soon as Postprint is submitted to ZB.
Drug-based optical agents: Infiltrating clinics at lower risk.
Sci. Transl. Med. 4:134ps11 (2012)
Fluorescent agents with specificity to cellular and subcellular moieties present promise for enhancing diagnostics and theranostics, yet challenges associated with regulatory approvals of experimental agents stifle the clinical translation. As a result, targeted fluorescent agents have remained predominantly as preclinical imaging tools. We discuss the potential of using optically labeled drugs to accelerate the clinical acceptance of optical and optoacoustic agents, in analogy to nuclear medicine approaches. This strategy, corroborated with microdosing studies, outlines a promising approach for overcoming bottlenecks and advancing photonic clinical imaging.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
COLORECTAL-CANCER; IN-VIVO; PET; ONCOLOGY
ISSN (print) / ISBN
1946-6234
e-ISSN
1946-6242
Journal
Science Translational Medicine
Quellenangaben
Volume: 4,
Issue: 134,
Article Number: 134ps11
Publisher
American Association for the Advancement of Science (AAAS)
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)