PuSH - Publication Server of Helmholtz Zentrum München: NC2 mobilizes TBP on core promoter TATA boxes.

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Schluesche, P.* ; Stelzer, G. ; Piaia, E. ; Lamb, D.C.* ; Meisterernst, M.

NC2 mobilizes TBP on core promoter TATA boxes.

Nat. Struct. Mol. Biol. 14, 1196-1201 (2007)

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The general transcription factors (GTFs) of eukaryotic RNA polymerase II, in a process facilitated by regulatory and accessory factors, target promoters through synergistic interactions with core elements. The specific binding of the TATA box-binding protein (TBP) to the TATA box has led to the assumption that GTFs recognize promoters directly, producing a preinitiation complex at a defined position. Using biochemical analysis as well as biophysical single-pair Förster resonance energy transfer, we now provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode. This can lead to movement of TBP along the DNA away from TATA.

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