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Open Access Green as soon as Postprint is submitted to ZB.
Urocortin 2 modulates aspects of social behaviour in mice.
Behav. Brain Res. 233, 331-336 (2012)
Urocortin 2 (UCN2), a member of the corticotropin-releasing hormone family, is involved in the regulation of stress-related behaviours in rodents. To determine its physiological function we generated mice lacking UCN2 by applying a classical knockout strategy. We examined hypothalamus-pituitary-adrenocortical axis activity, anxiety- and depression-related behaviours without finding significant differences between mutant and wild-type littermates. Investigating social abilities we observed, that male, but not female, UCN2 knockout animals showed an altered social behaviour. Here we report that male UCN2 null mice showed more passive social interactions and reduced aggressiveness in comparison to wild-type animals. In conclusion, UCN2 seems to modulate aggressive behaviour in male mice. Furthermore, our findings provide additional evidence for previously reported sex-specific effects of UCN2.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Urocortin2; Knockout; CRH-R2, Social Behaviour; Attack latency test; Social interaction; CORTICOTROPIN-RELEASING-FACTOR; IMPAIRED STRESS-RESPONSE; HORMONE-RECEPTOR 1; MATERNAL DEFENSE; CRF RECEPTORS; ANXIETY; TYPE-2; ADAPTATIONS; ACTIVATION; DEFICIENT
ISSN (print) / ISBN
0166-4328
e-ISSN
1872-7549
Journal
Behavioural Brain Research
Quellenangaben
Volume: 233,
Issue: 2,
Pages: 331-336
Publisher
Elsevier
Non-patent literature
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Reviewing status
Peer reviewed