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Okada, Y.* ; Sim, X.* ; Go, M.J.* ; Wu, J.Y.* ; Gu, D.F.* ; Takeuchi, F.* ; Takahashi, A.* ; Maeda, S.* ; Tsunoda, T.* ; Chen, P.* ; Lim, S.C.* ; Wong, T.Y.* ; Liu, J.J.* ; Young, T.L.* ; Aung, T.* ; Seielstad, M.* ; Teo, Y.Y.* ; Kim, Y.J.* ; Lee, J.Y.* ; Han, B.G.* ; Kang, D.* ; Chen, C.H.* ; Tsai, F.J.* ; Chang, L.C.* ; Fann, S.J.C.* ; Mei, H.* ; Rao, D.C.* ; Hixson, J.E.* ; Chen, S.F.* ; Katsuya, T.* ; Isono, M.* ; Ogihara, T.* ; Chambers, J.C.* ; Zhang, W.H.* ; Kooner, J.S.* ; Albrecht, E. ; Yamamoto, K.* ; Kubo, M.* ; Nakamura, Y.* ; Kamatani, N.* ; Kato, N.* ; He, J.* ; Chen, Y.T.* ; Cho, Y.S.* ; Tai, E.S.* ; Tanaka, T.*

Meta-analysis identifies multiple loci associated with kidney function-related traits in East Asian populations.

Nat. Genet. 44, 904-909 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-Wide Association; Cardiovascular-Disease Risk; Body-Mass Index; Common Variants; Japanese Population; Blood-Pressure; Expression; Slc2a9; Gout; MAP
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 44, Issue: 8, Pages: 904-909 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)