PuSH - Publication Server of Helmholtz Zentrum München

Hartz, S.M.* ; Short, S.E.* ; Saccone, N.L.* ; Culverhouse, R.* ; Chen, L.* ; Schwantes-An, T.H.* ; Coon, H.* ; Han, Y.* ; Stephens, S.H.* ; Sun, J.* ; Chen, X.* ; Ducci, F.* ; Dueker, N.* ; Franceschini, N.* ; Frank, J.* ; Geller, F.* ; Gubjartsson, D.* ; Hansel, N.N.* ; Jiang, C.* ; Keskitalo-Vuokko, K.* ; Liu, Z.* ; Lyytikäinen, L.-P.* ; Michel, M.* ; Rawal, R. ; Rosenberger, A.* ; Scheet, P.* ; Shaffer, J.R.* ; Teumer, A.* ; Thompson, J.R.* ; Vink, J.M.* ; Vogelzangs, N.* ; Wenzlaff, A.S.* ; Wheeler, W.* ; Xiao, X.* ; Yang, B.Z.* ; Aggen, S.H.* ; Balmforth, A.J.* ; Baumeister, S.E.* ; Beaty, T.* ; Bennett, S.* ; Bergen, A.W.* ; Boyd, H.A.* ; Broms, U.* ; Campbell, H.* ; Chatterjee, N.* ; Chen, J.* ; Cheng, Y.C.* ; Cichon, S.* ; Couper, D.* ; Cucca, F.* ; Dick, D.M.* ; Foroud, T.* ; Furberg, H.* ; Giegling, I.* ; Gu, F.* ; Hall, A.S.* ; Hällfors, J.* ; Han, S.* ; Hartmann, A.M.* ; Hayward, C.* ; Heikkilä, K.* ; Hewitt, J.K.* ; Hottenga, J.J.* ; Jensen, M.K.* ; Jousilahti, P.* ; Kaakinen, M.* ; Kittner, S.J.* ; Konte, B.* ; Korhonen, T.* ; Landi, M.T.* ; Laatikainen, T.* ; Leppert, M.* ; Levy, S.M.* ; Mathias, R.A.* ; McNeil, D.W.* ; Medland, S.E.* ; Montgomery, G.W.* ; Muley, T.* ; Murray, T.* ; Nauck, M.* ; North, K.* ; Pergadia, M.* ; Polasek, O.* ; Ramos, E.M.* ; Ripatti, S.* ; Risch, A.* ; Ruczinski, I.* ; Rudan, I.* ; Salomaa, V.* ; Schlessinger, D.* ; Styrkarsdottir, U.* ; Terracciano, A.* ; Uda, M.* ; Willemsen, G.* ; Wu, X.* ; Abecasis, G.* ; Barnes, K.* ; Bickeböller, H.* ; Boerwinkle, E.* ; Boomsma, D.I.* ; Caporaso, N.* ; Duan, J.* ; Edenberg, H.J.* ; Francks, C.* ; Gejman, P.V.* ; Gelernter, J.* ; Grabe, H.J.* ; Hops, H.* ; Jarvelin, M.R.* ; Viikari, J.* ; Kähönen, M.* ; Kendler, K.S.* ; Lehtimäki, T.* ; Levinson, D.F.* ; Marazita, M.L.* ; Marchini, J.* ; Melbye, M.* ; Mitchell, B.D.* ; Murray, J.C.* ; Nöthen, M.M.* ; Penninx, B.W.* ; Raitakari, O.* ; Rietschel, M.* ; Rujescu, D.* ; Samani, N.J.* ; Sanders, A.R.* ; Schwartz, A.G.* ; Shete, S.* ; Shi, J.* ; Spitz, M.* ; Stefansson, K.* ; Swan, G.E.* ; Thorgeirsson, T.* ; Völzke, H.* ; Wei, Q.* ; Wichmann, H.-E. ; Amos, C.I.* ; Breslau, N.* ; Cannon, D.S.* ; Ehringer, M.* ; Grucza, R.* ; Hatsukami, D.* ; Heath, A.* ; Johnson, E.O.* ; Kaprio, J.* ; Madden, P.* ; Martin, N.G.* ; Stevens, V.L.* ; Stitzel, J.A.* ; Weiss, R.B.* ; Kraft, P.* ; Bierut, L.J.*

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

JAMA psychiatry 69, 854-860 (2012)
DOI PMC
CONTEXT Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES Primary data. STUDY SELECTION Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION Uniform statistical analysis scripts were run locally. Starting with 94 050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13 843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19 505) (P = .01). CONCLUSION These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords NICOTINIC RECEPTOR GENES; GENOME-WIDE ASSOCIATION; LUNG-CANCER; SUSCEPTIBILITY LOCUS; HEAVY SMOKING; ADULT RATS; DEPENDENCE; ADOLESCENT; INITIATION; RISK
ISSN (print) / ISBN 2168-622X
e-ISSN 2168-6238
Journal JAMA Psychiatry
Quellenangaben Volume: 69, Issue: 8, Pages: 854-860 Article Number: , Supplement: ,
Publisher American Medical Association
Publishing Place Chicago, Ill.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)