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Open Access Green as soon as Postprint is submitted to ZB.
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis.
Lancet 380, 680-688 (2012)
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is characterised by altered cellular composition and homoeostasis in the peripheral lung, leading to excessive accumulation of extracellular matrix and, ultimately, loss of lung function. It is the interstitial pneumonia with the worst prognosis-mortality 3-5 years after diagnosis is 50%. During the past decade, researchers have described several novel cellular and molecular mechanisms and signalling pathways implicated in the pathogenesis of idiopathic pulmonary fibrosis, resulting in the identification of new therapeutic targets. These advances will hopefully result in increased survival rates and improved quality of life for patients with this disorder in future.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
EPITHELIAL-MESENCHYMAL TRANSITION; USUAL INTERSTITIAL PNEUMONIA; COLLAGEN-PRODUCING CELLS; PROSTAGLANDIN E-2; MYOFIBROBLAST DIFFERENTIATION; STEM-CELLS; GASTROESOPHAGEAL-REFLUX; FIBROBLASTIC FOCI; RENAL FIBROSIS; SONIC HEDGEHOG
ISSN (print) / ISBN
0140-6736
e-ISSN
0099-5355
Journal
Lancet, The
Quellenangaben
Volume: 380,
Issue: 9842,
Pages: 680-688
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)