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Saab, A.S.* ; Neumeyer, A.* ; Jahn, H.M.* ; Cupido, A.* ; Simek, A.A.M.* ; Boele, H.J.* ; Scheller, A.* ; Le Meur, K.* ; Götz, M. ; Monyer, H.* ; Sprengel, R.* ; Rubio, M.E.* ; Deitmer, J.W.* ; de Zeeuw, C.I.* ; Kirchhoff, F.*

Bergmann glial AMPA receptors are required for fine motor coordination.

Science 337, 749-753 (2012)
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The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Kainate Receptors ; Plasticity ; Cerebellum ; Cells ; Communication
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 337, Issue: 6095, Pages: 749-753 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
DOI 10.1126/science.1221140
WOS ID WOS:000307354500059
Scopus ID 84864857173
PubMed ID 22767895
Erfassungsdatum 2012-09-13
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