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Degroote, R.L.* ; Hauck, S.M. ; Kremmer, E. ; Amann, B.* ; Ueffing, M. ; Deeg, C.A.*

Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis.

J. Proteomics 75, 4536-4544 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The molecular mechanism which enables activated immune cells to cross the blood-retinal barrier in spontaneous autoimmune uveitis is yet to be unraveled. Equine recurrent uveitis is the only spontaneous animal model allowing us to investigate the autoimmune mediated transformation of leukocytes in the course of this sight threatening disease. Hypothesizing that peripheral blood immune cells change their protein expression pattern in spontaneous autoimmune uveitis, we used DIGE to detect proteins with altered abundance comparing peripheral immune cells of healthy and ERU diseased horses. Among others, we found a significant downregulation of talin 1 in peripheral blood granulocytes of ERU specimen, pointing to changes in beta integrin activation and indicating a significant role of the innate immune system in spontaneous autoimmune diseases. This article is part of a Special Issue entitled: SI: Farm animal proteomics.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Immune Disease ; Dige ; Granulocytes ; Talin 1 ; Immunoproteomics ; Autoimmune; Equine Recurrent Uveitis; Multiple-Sclerosis; Integrin Activation; Dendritic Cells; Down-Regulation; Disease; Horses; Autoantigens; Binding; Domain
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 1874-3919
e-ISSN 1876-7737
Journal Journal of Proteomics
Quellenangaben Volume: 75, Issue: 14, Pages: 4536-4544 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) CF Metabolomics & Proteomics (CF-MPC)
Institute of Molecular Immunology (IMI)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Enabling and Novel Technologies
Immune Response and Infection
PSP Element(s) G-505700-001
G-501793-001
PubMed ID 22306886
DOI 10.1016/j.jprot.2012.01.023
WOS ID WOS:000307023900026
Scopus ID 84863834223
Erfassungsdatum 2012-09-21
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